Viral Sabotage of Mitochondria: An Ancient Biological Conflict Driving Cognitive Decline

Author: Stefano, George B.; Weissenberger, Simon; Ptacek, Radek; Anders, Martin; Raboch, Jiri; Büttiker, Pascal

A recent study coauthored by Dr. Simon Weissenberger reveals how certain viruses have evolved sophisticated strategies to disrupt mitochondrial function—a process increasingly linked to cognitive decline and neurodegeneration. Mitochondria, often described as the cell’s powerhouses, are of bacterial origin and are essential for sustaining neuronal health. The researchers propose that the interaction between viruses and mitochondria may stem from a deep evolutionary relationship, rooted in ancient viral-bacterial conflicts. This co-evolutionary dynamic could help explain how modern viruses exploit mitochondrial pathways to impair brain function.

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